IL6 and neoplasm: Özeş AR, etc [31] showed that HOTAIR could affects platinum resistance in ovarian cancer by down-regulating NF-κB inhibitor Iκ-Bα, prolonging NF-κB activity, activating its downstream protein interleukin-6 expression to activate DNA damage response pathway (DDR), ultimately maintained tumor cell genome stability, maintain cell survival and avoided apoptosis.