Özeş AR, etc [31] showed that HOTAIR could affects platinum resistance in ovarian cancer by down-regulating NF-κB inhibitor Iκ-Bα, prolonging NF-κB activity, activating its downstream protein interleukin-6 expression to activate DNA damage response pathway (DDR), ultimately maintained tumor cell genome stability, maintain cell survival and avoided apoptosis. The gene discussed is NFKB1; the disease is ovarian cancer.