MAPT and Alzheimer disease: Similar results have been reported recently, however using other experimental conditions: different tau variants (full-length 2N4R tau fibrils [27], full-length tau with P301S mutation, the cause of familial form of frontotemporal dementia (FTD) rather than AD [21]), or utilizing a non-neuronal cell based seeding assays [88] which requires facilitation of tau seeding with additional protein carriers (lipofectamine) [15].