We further assess the expression pattern of CSTF2 in lung cancer samples in The Cancer Genome Atlas database (TCGA), and the results from 100 paired TCGA clinical samples showed near twofolds change of up-regulated CSTF2 expression in cancer cells versus normal lung cells, which is in consistence with the CSTF2 expression pattern of our clinical samples (Fig. 3d). The gene discussed is CSTF2; the disease is cancer.