Of note, of the identified 1855 genes (FDR = 0.01) with a significant difference of the 3′UTR length that may link tandem 3′UTR length switching with the pathologic process of lung cancer, we detected alternative isoforms of Cyclin D1, DICER1, RAB10, Cyclin D2, FGF2 in all clinical cancer samples, and alternative isoform of IMP-1 in a remarkable portion of the samples (Additional file 3: Fig. S2). Here, CCND2 is linked to cancer.