MAPK4 and cancer: For example, FGF2 (fibroblast growth factor 2, uc003iev.1), which shows 0.3 fold-change of down-regulation in cancer tissue (P-value = 1.85e−4), has been demonstrated to play vital roles in tumor angiogenesis and lymphangiogenesis of lung cancer [19, 20]; MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4, uc002tbc.2), which shows 1.2 fold-change of upregulation in cancer tissue (P-value = 0.037), contributes to cell proliferation, anchorage-independent growth and cancer cell migration of lung cancer [21].