RARB and invasive breast carcinoma: Moreover, the TCGA database also showed that NR1B2 was down-regulated in various types of human cancer, such as Kidney renal papillary cell carcinoma (KIRP), bladder cancer (BLCA), breast cancer (BRCA), Head and Neck squamous cell carcinoma (HNSC), Lung adenocarcinoma (LUAD), Thyroid carcinoma (THCA) and Uterine Corpus Endometrial Carcinoma (UCEC), which further suggested that NR1B2 might play an tumor suppressor role in the progression or development of urologic and various human cancer types.