FOXP3 expression was significantly lower in large tumors (> 2 cm; rFOXP3 = − 0.38, p = 0.018) and in lobular carcinomas (rFOXP3 = − 0.59, p = 0.015; Fig. 1f), compared with ductal carcinomas (p < 0.001; Additional file 1: Figure S4I). This evidence concerns the gene FOXP3 and breast lobular carcinoma.