Different subpopulations of T lymphocytes regulate the balance of immune tolerance and pro-inflammatory status in tumors [17, 28–30]: CD8-positive cytotoxic T lymphocytes are involved in interferon gamma (IFNγ)–dependent mechanisms of antitumor activity [11, 28, 29]; CD4-positive helper T lymphocytes are important in activating and regulating the adaptive immune response [28, 30]; in contrast, FOXP3-positive regulatory T lymphocytes have a crucial role in protecting tissues from inflammation damage and preventing autoimmunity [13, 30]. This evidence concerns the gene IFNG and Autoimmunity.