Our study shows that cytoplasmic PAX8 was slightly increased in PC cells with overexpressed MACC1-AS1, resulting in promoted aerobic glycolysis, indicating that PC carcinogenesis and development were facilitated by MACC1-AS1 via modulating activities of both pyruvate kinase and protein kinase of PAX8. The gene discussed is WEE1; the disease is pachyonychia congenita.