MACC1 and pachyonychia congenita: Then, we checked the expression of MACC1-AS1 in an extended PC cohort, indicating that compared to NCTs (P < 0.01), it was dramatically increased in PC tissues and that compared to NCTs, 63.3% (62 of 98) of the PC tissues showed upregulation of MACC1-AS1 (Fig. 1b).