Among this set of miRNAs, eight (hsa-miR-1181, hsa -miR-1207-3p, hsa -miR-1246, hsa -miR-3180, hsa -miR-3960, hsa -miR-4436a, hsa -miR-517a-3p, hsa -miR-517a-3p) were determined to target two or more transcripts from the set of 6 network-central predictor genes, with the exception of SFXN2. The increased correlation between the stroke related miRNAs identifiable in blood and the set of predictor genes provides an additional validation of the statistical and potentially functional significance of these genes as stroke biomarkers. This evidence concerns the gene SFXN2 and Stroke.