The third pattern was where extreme MAF changes occurred in the metastases as compared to the primary tumor: BRAF mutant cases 4,6–9 on Fig. 3a., case No1 on Fig. 3b and cases 1,4 and 7–9 on Fig. 3c, NRAS mutants cases No4 and 11 on Fig. 4. The gene discussed is BRAF; the disease is neoplasm.