NRAS and neoplasm: The third pattern was where extreme MAF changes occurred in the metastases as compared to the primary tumor: BRAF mutant cases 4,6–9 on Fig. 3a., case No1 on Fig. 3b and cases 1,4 and 7–9 on Fig. 3c, NRAS mutants cases No4 and 11 on Fig. 4.