The peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) protein is encoded by this gene and plays a role in energy metabolism, including insulin resistance, oxidative phosphorylation, hepatic gluconeogenesis, and mitochondrial biogenesis and respiration, which are important in the development of NAFLD [6]. Here, PPARGC1A is linked to metabolic dysfunction-associated steatotic liver disease.