NQO1 and diabetic cardiomyopathy: As expected, H2S could activate the Nrf2 signaling pathway together with the upregulations of antioxidant proteins haem oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), thus alleviating the development of diabetic cardiomyopathy via attenuation of oxidative stress in the heart [115].