Compared with adjacent normal tissues, tumor samples exhibited hypermethylation of Estrogen Receptor 1, Cadherin 13, Retinoic Acid Receptor Beta, Cell Surface Adhesion Molecule, and Adenomatous Polyposis Coli (ESR1, CDH13, RARB, IGSF4, and APC) genes [77]. The gene discussed is APC; the disease is Familial adenomatous polyposis.