Compared with adjacent normal tissues, tumor samples exhibited hypermethylation of Estrogen Receptor 1, Cadherin 13, Retinoic Acid Receptor Beta, Cell Surface Adhesion Molecule, and Adenomatous Polyposis Coli (ESR1, CDH13, RARB, IGSF4, and APC) genes [77]. Here, RARB is linked to Familial adenomatous polyposis.