ALOX5 and cancer: To confirm the implication of 5-LO in the pathogenesis of cancer, researchers have used several medications such as 5-LO inhibitors (zileuton, ZYflo, ABT-761), FLAP inhibitors (MK-886) or other related drugs (zafirlukast and montelukast) in inhibiting cell proliferation and inducing cell death in vitro and in vivo [11].