Considering that global transcriptomic analysis suggested that KDM3A and KDM4B co-operate to drive a pro-proliferative phenotype and that dual knockdown of each enzyme down-regulated ER-target genes more than individual KDM3A and KDM4B depletion, we next assessed the effect of dual-knockdown on BC cell growth. The gene discussed is KDM3A; the disease is breast cancer.