For example, data derived from microarrays and proteomics have shown reduced expression of various components of the regulated secretory pathway (e.g., SNAP25, syntaxin, rabphilin 3A, annexin) in VHL-related pheochromocytomas compared to RET-related pheochromocytomas [169]. The gene discussed is VHL; the disease is hereditary pheochromocytoma-paraganglioma.