Despite their efficacy, these medications can exhibit minor or even severe side effects: Beta-blockers may worsen symptoms of asthma and other lung diseases; diuretics can provoke reversible impotence and gout attacks; angiotensin-converting enzyme (ACE) inhibitors can induce persistent dry cough and angioedema; calcium channel blockers (CCB) can cause peripheral edema, headache, flushing, and tachycardia [5]. This evidence concerns the gene ACE and Impotence.