CASP8 and neoplasm: Effects were additive for ING4 and IL-24, and in addition up-regulation of the tumor suppressors p21, p27, fas cell surface death receptor (Fas), Bax, and the apoptosis-promoting cleaved caspases-8, -9, -3, and down-regulation of the tumor-promoter Bcl-2 apoptosis regulator (Bcl-2) was observed [41].