CTNNB1 and lung cancer: The conclusion drawn from this study was an evident inhibition of EMT and lung cancer invasion via blocking the WNT/beta-catenin pathway by ING5. Another report showed ING5 to exert tumor-suppressive properties, its knockdown in A549 cells leading to an up-regulation of the EGFR/PI3K/Akt and IL-6/STAT3 oncogenic pathways [59].