The p21waf1 protein was significantly up-regulated, and a complex of p33ING1b and wtp53 could be detected after the wtp53 lung cancer cells had been transfected by ING1b. LOH correlated inversely with the expression of p33ING1b, and p33ING1b expression was lost in the majority (53%) of lung cancer specimens overall [22]. The gene discussed is ING1; the disease is lung cancer.