We examined global transcriptome alterations following depletion of DNA replication checkpoint genes (Atr, Mcm4, Mcm5, and Mcm6), the Fanconi anemia gene (Fanca), mRNA processing genes (Snrpal and Snrpd3), and CMT genes (Sh3tc2 and Cmt4b2). The gene discussed is MCM5; the disease is anemia.