Intense efforts are currently underway to address acquired resistance to Bor, which results in recurrence and poor prognoses for patients with MM during long‐term Bor treatment.3, 54, 55 For the first time, we identified a novel gene, NEDD4‐1, that may play a key role in the development of Bor resistance in MM. This evidence concerns the gene NEDD4 and Miyoshi myopathy.