While NEDD4‐1 is an oncogene in most cancers,16, 17, 18, 19, 20, 21, 22, 33, 34 it can also act as a tumor suppressor in some tumors14, 15, 35, 36; however, the role of NEDD4‐1 in MM remains unclear. The gene discussed is NEDD4; the disease is cancer.