The RING finger family E3 ligase TRAF6 ubiquitinates Akt and strengthens Akt membrane recruitment and phosphorylation, which are dependent on growth factor stimulation.27 Furthermore, NEDD4‐1 is an E3 ligase targeting Akt for phosphorylation and nuclear trafficking in the IGF‐I response.28, 29 Therefore, we evaluated how Akt can be regulated by NEDD4‐1 E3s in MM and whether it plays a role in Bor sensitivity. Here, IGF1 is linked to Miyoshi myopathy.