To explore the role of NEDD4‐1 in Akt ubiquitination in MM, the lysates of NEDD4‐1‐KD and NEDD4‐1‐OE MM cells were immunoprecipitated with anti‐Akt and anti‐pAkt‐Ser473 antibodies, while Akt and pAkt‐Ser473 ubiquitination were detected with antibodies against ubiquitin. This evidence concerns the gene NEDD4 and Miyoshi myopathy.