The exfoliative toxin A gene (eta), known for causing staphylococcal scalded skin syndrome, and the transcriptional Repressor SaPI gene (stl), which controls the retention of the Staphylococcus aureus pathogenicity islands (SaPIs) in the host chromosome, were only found in the genomes of strains associated with clinical mastitis. This evidence concerns the gene RNF217-AS1 and staphylococcal scalded skin syndrome.