Furthermore, in a phase II randomized trial evaluating neoadjuvant chemotherapy regimens with weekly paclitaxel or E followed by doxorubicin and cyclophosphamide in women with locally advanced HER2-negative breast cancer, pCR was lower in the E arm than in the paclitaxel one (17 versus 26%) [33]. Here, ERBB2 is linked to breast carcinoma.