There was no strong or suggestive evidence for an association of sex hormone binding globulin (OR per unit increase in natural-log-transformed sex hormone binding globulin [nmol/l]: 1.09, 95% CI 0.88–1.35; P = 0.45) or circulating 25-hydroxyvitamin D (OR per unit increase in natural-log-transformed 25-hydroxyvitamin D [ng/ml]: OR 1.02, 95% CI 0.72–1.44; P = 0.93) with invasive epithelial ovarian cancer risk (Fig 6; Table 2) or with subtype-specific ovarian cancer (S5 Table). The gene discussed is SHBG; the disease is ovarian carcinoma.