For example, such conformational changes have been seen for: Aβ, associated with Alzheimer’s disease; α-synuclein with Parkinson’s disease; TDP-43, FUS and others with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); and huntingtin with Huntington’s disease. The gene discussed is TARDBP; the disease is frontotemporal dementia.