Clinical suspicion of PCa, based on elevated PSA level (PSA<20 ng/mL or free-to-total PSA ratio ≤0.15 and PSA<10 ng/mL in repeated measurements); no evidence of PSA level increase due to noncancerous factors (ie, urinary tract infection); negative DRE findings. This evidence concerns the gene KLK3 and posterior cortical atrophy.