BRCA1 and ovarian carcinoma: Currently, bilateral salpingo-oophorectomy is strongly recommended for individuals with BRCA1 or BRCA2 mutations to prevent ovarian cancer and has also been shown to affect overall survival.1,26 Interventions to reduce bone disease (and other adverse noncancer outcomes, including cardiovascular disease or cognitive decline) are necessary and may include a combination of HT use or lifestyle interventions, such as physical activity or supplement use.