In addition, we (and others) have reported improved management of menopausal symptoms (including quality of life and sexual health) with HT use following oophorectomy in the same cohort of women.20 Furthermore, a recent prospective study of HT use following oophorectomy29 found no significant association of estrogen-alone HT with breast cancer risk among individuals with a BRCA1 mutation. This evidence concerns the gene BRCA1 and breast cancer.