Since RAC2, PAK4, and BCL2L1 were validated to be targeted by miR‐608, cell function assays using siRNAs of RAC2/PAK4/BCL2L1, and RAC2/PAK4/BCL2L1 rescue experiments were conducted to further elucidate the association between miR‐608 and RAC2/PAK4/BCL2L1 in PCa. Here, PAK4 is linked to posterior cortical atrophy.