DNMT1 and posterior cortical atrophy: MiRNA expression could be epigenetically regulated by CpG‐island methylation, namely methyl groups transferring to the cytosine residues of CpG‐dinucleotide repeats achieved by DNA methyltransferases (DNMT).13 Methylated CpG‐island near TSS could silence the corresponding miRNA gene via transcriptive inhibition.14, 15 Therefore, to explore the mechanisms of miR‐608 downregulation in PCa cell lines and tissues, BSP was employed to investigate the methylation state of CpG‐islands close to miR‐608 TSS.