As the insulin/IR/IRS/PI3K/Akt/GLUT4 pathway plays an important role in T2DM, we investigate the association between 12 SNPs in 9 miRNAs (rs10459194 in miR‐135a‐2, rs10993081 and rs7045890 in let‐7d, rs2296616 in miR‐107, rs2402959 and rs6965643 in miR‐96, rs24168 in miR‐29a, rs3745453 in miR‐23a, rs4636297 in miR‐126, rs8089787 and rs9948906 in miR‐133a‐1 and rs999885 in miR‐106b), which were reported to be directly or indirectly involved in the insulin/IR/IRS/PI3K/Akt/GLUT4 pathway, and T2DM in a Chinese population. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.