The immunohistochemistry (Figure 1E,F) and RT‐qPCR (Figure 1G) results demonstrated that compared with the adjacent normal tissues, the positive expression rate of HOXC8 as well as the expression of HOTAIR was considerably elevated in the oesophageal cancer tissues, while the expression of miR‐204 was notably decreased (all P < 0.05). Here, HOTAIR is linked to carcinoma of esophagus.