Agreeing with our results, Dai et al.10reported that the liver biopsies of chronic hepatitis B patients showed bothCB1 receptor overexpression and increased α-SMA count in fibrotic livers.Teixeira-Clerc et al.5used biopsies of human chronic liver disease and they reported that culturedhuman and mouse liver fibrogenic cells and activated HSCs also expressed CB1receptors. This evidence concerns the gene ACTA1 and chronic hepatitis B virus infection.