Next, we used targeted next generation sequencing (TNGS) for the remaining 25 individuals and identified 20 different variants in 14 genes (SLC26A4, KCNQ4, MYO7A, MYO15A, TMPRSS3, ESPN, TMC1, GIPC3, LHFPL5, WFS1, DFNB59, GRXCR1, ESRRB, and LRTOMT).<h4>Conclusions</h4>We described common and novel variants in 15 genes in a Pakistani cohort of NSHL. The gene discussed is LRTOMT; the disease is nodular sclerosis classical Hodgkin lymphoma.