A combination of plasma biomarkers, including NfL, which has recently been shown to be related to dementia status and age in DS individuals (Fortea et al., 2018; Strydom et al., 2018), markers of oxidative stress (Coppus, Fekkes, Verhoeven, Tuinier, & van Duijn, 2010; Zis, Dickinson, Shende, Walker, & Strydom, 2012; Zis et al., 2014), and of inflammation (Startin et al., 2019) could be explored for improved prediction. The gene discussed is NEFL; the disease is Dravet syndrome.