FLOT1 and cancer: This finding suggested that gene silencing caused by methylation in the promoter of the miR‐124 encoding gene may be one reason for the decrease in miR‐124 in cancer cells with strong migration ability and may be a disadvantageous independent prognostic factor in BC patients.53 Li et al identified flotillin‐1 (FLOT1) as a direct downstream gene of miR‐124, and low miR‐124 expression restrained FLOT1 by acting on the 3'‐UTR of FLOT1, as confirmed by luciferase assays.54 They also found that miR‐124 was decreased in pathological BC tissues.