Alox15 overexpression could induce osteoarthritis (Chen, Cai, et al., 2017a; Chen, Yan, et al., 2017b), tumorigenesis (Kelavkar et al., 2001), hypotension (Aggarwal et al., 2008), and anxiety (Joshi, DiMeco, & Pratico, 2014); Slc5a7 overexpression elevated acetylcholine levels and augmented motor endurance (Holmstrand et al., 2014); Fut2 overexpression also promoted cell proliferation, migration, and tumorigenicity (Lai et al., 2019) in mice. This evidence concerns the gene SLC5A7 and osteoarthritis.