With respect to TNF‐α, systemic factors, that is, hyperinsulinemia, might trigger the increased arterial presence of this pro‐inflammatory cytokine in 6‐month‐old Cc1−/− mice as suggested, since we were unable to detect TNF‐α in our cultured endothelial cells under basal conditions. The gene discussed is TNF; the disease is Hyperinsulinemia.