Whenever a B cell lymphoma with a DLBCL morphology displays either a GCB COO and/or a double expression of MYC and BCL2 proteins (in more than 40% and 50% of neoplastic cells, respectively) (DE DLBCL), analysis of MYC, BCL2, and BCL6 gene rearrangements by FISH is indicated in order to rule out the possibility of a HGBL DH/TH. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.