MYC and diffuse large B-cell lymphoma: In addition to its role in discriminating different DLBCL prognostic subgroups (non-GCB carrying worse prognosis in comparison with GCB type), determination of COO might help in identifying those cases potentially harboring rearrangements of MYC, BCL2, and BCL6. Indeed, almost all the HGBL DH/TH fall within the GCB subtype with less than 1% of ABC harboring MYC and BCL2 and 2% MYC and BCL6 rearrangements [3].