In population 1, the serum S100B in the samples drawn 6 h or less from trauma (12/201 patients with intracranial hemorrhage) had the best cutoff at 0.1 μg/l (AUC = 0.589, 95% CI 0.436–0.741, p = 0.304). The gene discussed is S100B; the disease is intracranial hemorrhage.