Renovascular HTN is suspected among patients with HTN beginning at the age of ≤30 or ≥ 55 years, worsening of previously well-controlled HTN, an abdominal bruit, resistant HTN, an increase in the creatinine level of > 30% over the baseline level following the administration of an angiotensin converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB), and the presence of atherosclerotic disease in other organs. This evidence concerns the gene ACE and hypertensive disorder.