BAX and cancer: Isolated from the root tissues of Lithospermum erythrorhizon and known in Chinese traditional medicine for many years for the treatment of sore throat, burns, cuts and skin diseases, shikonin (11) acts in a variety of molecular targets that are associated to the genesis of cancer, such as the upregulation of p53 and increased expression of apoptosis regulator BAX (Bax) [45, 46].