To investigate the mechanism of KIF26B on the function of HCC cells, we identified the top 800 genes which were the highest correlation with KIF26B expression in the TCGA liver cancer database for KEGG and GO analysis, and the result showed that PI3K/AKT signaling pathway was the significant enrichment (Fig. 5a, b). This evidence concerns the gene AKT1 and hepatocellular carcinoma.