POLE and cervical squamous intraepithelial neoplasia: While the prognostic factors MMR-D/POLE mutation and CIN were also significantly associated with TTR in univariable analyses, only CD8+ density remained prognostic in multivariable analyses (HR = 0.92; 95% CI = 0.87–0.97, P = 3.6 × 10−3) (Table 2, S7, Fig. 2a).