CD8A and colorectal carcinoma: In light of these findings, we proceeded to use the results obtained from analysis of TMA cores to examine the association of CD8+ and CD3+ cell density, alone and in combination, with time to CRC recurrence (TTR) in this trial population, given the known prognostic value of these markers in CRC.7,14 This revealed that intratumoural CD8, but not CD3, was significantly associated with TTR in univariable analysis, and in a model that included both markers (Table S4).