CD8A and neoplasm: Complementary analysis of whole tissue sections in a subset of 51 cases revealed similar positive correlations between estimates of CD8+ infiltrate in the tumour centre with those from TMA cores (Spearman rho 0.64; P = 3.1 × 10−5), and between CD8+ cell density in the tumour centre and invasive margin (Spearman rho 0.73, P = 1.3 × 10−9).