In contrast, corresponding univariable and confirmatory multivariable analysis suggested this association (between CD8+ cell infiltrate and TTR) differed between pT1-3 vs. pT4 tumours (multivariable-adjusted HR = 0.96, 95% CI = 0.89–1.04, P = 0.35 vs. HR = 0.87, 95% CI = 0.80–0.95, P = 1.9 × 10−3), and to a lesser extent, between node negative and node positive tumours (HR = 0.94, 95% CI = 0.84–1.06, P = 0.31; and HR = 0.91, 95% CI = 0.85–0.97, P = 5.0 × 10−3, respectively). This evidence concerns the gene CD8A and neoplasm.