TTR and neoplasm: As pT4 primary and node positivity portended similarly reduced TTR in multivariable analysis (Table 1), and pT4,N0 and pT1-3,N1/2 tumours had very similar outcome in the pooled trials (Fig. S1A), we grouped tumours into low (pT1-3, N0), intermediate (pT4, N0 or pT1-3, N1 or N2) and high (pT4, N2) risk groups and examined the correlation of CD8+ cell density with TTR across these strata.