Significantly, we observed a decreased survival (log-rank, 0.0468), a shift to more proximal small intestinal adenoma (p = 0.0469) and an increase in distal small intestinal adenoma (p = 0.0149), with increased Ki-67 labelling of small intestinal adenoma (p = 0.0302), when comparing to Lgr5CreERT2, Apcloxp/loxp littermate controls (Fig. 7a-d). Here, MKI67 is linked to adenoma of small intestine.