In ApcMin/+, H19Δm/+p, there appeared no significant increase in adenoma number, whereas in ApcMin/+, Igf2r+m/R2Δ there was a significant reduction in the middle part of the small intestine (p = 0.0187), compatible with Igf2r having adenoma suppressor function. The gene discussed is IGF2R; the disease is adenoma.