At the SYTL3 locus, we identified a SNP associated with borderline PAD (rs317789, p < 10−6) in a close proximity (700 bp) to a previously reported association with the ABI in Europeans (rs2171209), although rs317789 is not correlated with rs2171209 in European or Hispanic populations. The gene discussed is SYTL3; the disease is peripheral arterial disease.