The functional annotation results showed COMMD10 variants overlapping putative regulatory regions in adventitial fibroblast cells, inflammatory macrophages and monocytes, suggesting that the regulatory variants in COMMD10 locus may be influencing the ABI or PAD via inflammatory and/or coagulation pathways, which is consistent with previously hypothesized roles for COMMD10. However, functional evaluation is needed to confirm the postulated underlying mechanisms. Here, COMMD10 is linked to peripheral arterial disease.