RAC1 and familial pancreatic carcinoma: Since Rac1 is a key mediator of EMT in pancreatic cancer, and it has been shown that the Rac1-related isoform, Rac1b, acts as an endogenous inhibitor of Rac1 in TGFβ signalling, we analyzed Rac1b and Rac1 + Rac1b expression in PRP treated cells by RTqPCR.