Moreover, our histological analysis of the xenografting mice models shows a decreased amount of tumour-surrounding fibrotic tissue of treated mice which can be explained by the strong down-regulation of TGFβ-1 by PRP treatment as TGFβ-1 has been described to be closely related to the corruption of healthy fibroblasts into cancer-associated fibroblasts (CAFs)61,62. The gene discussed is TGFB1; the disease is cancer.