Interleukin-1 β (IL-1β), Interleukin-10 (IL-10) and Interferon- γ (IFN-γ) were significantly higher in the first week of infection in mice infected at ZT3 compared to mice infected at ZT15 (p < 0.01, p < 0.01, p < 0.01 respectively) (Fig. 3C–E). Here, IL1B is linked to infection.