Angptl8 (also known as betatrophin, Lipasin, and C19orf80) belongs to the angiopoietin-like protein family, which includes 8 proteins structurally similar to the angiopoietins and are involved in the regulation of lipid metabolism, inflammation, cancer cell invasion, and hematopoietic stem activity20–23. The gene discussed is ANGPTL8; the disease is cancer.