Overall, a total 9 of the 30 mutational signatures referenced by COSMIC (Catalog of Somatic Mutations in Cancer) were seen at >1% mutational contribution in the WGS data (Supplementary Table 2); signature 1 related to aging1; 2 and 13 to activity of the APOBEC family of cytidine deaminases; 9 to polymerase η implicated with the activity of AID during somatic hypermutation1,18,19; signature 30 reflective of mismatch repair deficiency17; and signature 16 which has as yet an unknown etiology. This evidence concerns the gene CDA and cancer.