In addition to the induction by HGF, Hic-5 expression can also be induced during TGFβ1-triggered senescence of osteoblastic cell line4, angiotensin II-induced abdominal aortic aneurysm (AAA) development29, methylmercury-induced ER stress39, and Escherichia coli-induced prostatic inflammation40. Here, TGFB1I1 is linked to triple-A syndrome.