ATM and breast cancer: In a large-scale global study, Southey et al. [10] detected the mutation of PALB2 (partner and localizer of BC susceptibility gene 2), CHEK2 (checkpoint kinase 2), and ATM (ataxia telangiectasia-mutated gene), their study was deemed to be the world’s first research which demonstrated that rare genetic mutations also contributed to relatively high risks of BC.