In a large-scale global study, Southey et al. [10] detected the mutation of PALB2 (partner and localizer of BC susceptibility gene 2), CHEK2 (checkpoint kinase 2), and ATM (ataxia telangiectasia-mutated gene), their study was deemed to be the world’s first research which demonstrated that rare genetic mutations also contributed to relatively high risks of BC. Here, PALB2 is linked to breast cancer.