COL4A1 and microangiopathy and leukoencephalopathy, pontine, autosomal dominant: The location and nature of mutations affects clinical outcome with mutations affecting the CB3 region of α1(IV) causing the clinical subentity HANAC (hereditary angiopathy, nephropathy, aneurysm and cramps) syndrome, [63] and those in the miRNA-29 binding site of the 3′-UTR of COL4A1 the ischaemic small vessel disease PADMAL (pontine autosomal dominant microangiopathy with leukoencephalopathy) [64].