To test whether IFN-γ plays a role in BBB leakage during reovirus infection, we treated pups with a monoclonal neutralizing IFN-γ antibody (αIFN-γ) from 4 to 7 dpi and analyzed Biocytin-TMR leakage and vascular morphology (Fig. 4A). Here, IFNG is linked to Reoviridae infectious disease.