ADAM10 and Sepsis: In summary, we corroborated that the functional variant of rs653765 acts as an important genetic factor that confers the progression of sepsis in a large cohort and revealed that the rs653765 G→A variants modulate ADAM10 promoter activity by altering the binding of the EGR1 to the ADAM10 promoter, which then functionally activates ADAM10 gene expression and may influence the prognosis of sepsis.