Compared to that in the scrambled-sequence ODN (Sc-ODN) group, the EGR1 mRNA level was significantly reduced in the lung tissues of mice with LPS-induced sepsis, suggesting the knockdown efficiency of As-ODN (Fig. 4C), and consistent results were also observed in liver and kidney tissues with the intervention of As-ODN (Fig. S2G and K). This evidence concerns the gene EGR1 and Sepsis.