Our in vivo results showed that inhibition of EGR1 by specific As-ODN was associated with decreased ADAM10 expression with various efficiencies in kidney, liver, and lung tissues and was accompanied by reduced circulating proinflammatory marker generation and expression of tissue adhesion molecules, which ultimately rescued the survival and tissue injury of mice with endotoxemia. The gene discussed is EGR1; the disease is serum lipopolysaccharide activity.